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2. Bin Sun#, Jun Liu#, Yun Gao, Hongbo Zheng, Lin Li, Qingwen Hu, Huiqing Yuan, Hongxiang Lou*. (2017). Design, synthesis, and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome, European Journal of Medicinal Chemistry, 136, 603-618.

3. Bin Sun, Lin Li, Qingwen Hu, Hongbo Zheng, Hui Tang, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*. (2017). Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents, European Journal of Medicinal Chemistry, 129, 186-208

4. Chu-Hong Hu, Yan-Hui Zhou, Fei Xie, Yue-Lan Li, Zun-Tian Zhao & Hong-Xiang Lou*. (2017). Two new α-pyrone derivatives from an endolichenic fungus Tolypocladium sp, Journal of Asian Natural Products Research, 19 (8) ,787-792

5. Siwen Li, Hongzhuo Shi, Wenqiang Chang, Yi Li, Ming Zhang, Yanan Qiao, Hongxiang Lou*. (2017). Eudesmane sesquiterpenes from Chinese liverwort are substrates of Cdrs and display antifungal activity by targeting Erg6 and Erg11 of Candida albicans, Bioorganic & Medicinal Chemistry, 25(20), 5764-5771.

6. Xin-Yan Liu, Hai-NaYu, Shuai Gao, Yi-Feng Wu, Ai-Xia Cheng*, Hong-Xiang Lou*. (2017). The isolation and functional characterization of three liverwort genes encoding cinnamate 4-hydroxylase. Plant Physiology and Biochemistry, 117, 42-50.

7. Ming Zhang, Wenqiang Chang, Hongzhuo Shi, Yanhui Zhou, Sha Zheng, Ying Li, Lin Li, Hongxiang Lou*. (2017). Biatriosporin D displays anti-virulence activity through decreasing the intracellular cAMP levels. Toxicology and Applied Pharmacology, 322, 104-112.

8. Wenqiang Chang1, Ying Li 1, Ming Zhang, Sha Zheng, Yan Li, Hongxiang Lou*. (2017). Solasodine-3-O-β-d-glucopyranoside kills Candida albicans by disrupting the intracellular vacuole. Food and Chemical Toxicology, 106, 139-146.

9. Wenqiang Chang, Ying Li , Sha Zheng, Ming Zhang, Yanhui Gao, Hongxiang Lou*. (2017). Solasodine-3-O-β-D-glucopyranoside is hydrolyzed by a membrane glucosidase into active molecule solasodine against Candida albicans. Food and Chemical Toxicology, 109, 356-362.

10. Li W, Li XB, & Lou HX*. (2017). Structural and biological diversity of natural p-terphenyls. Journal of Asian Natural Products Research, 1-13.

11. Ye YQ, Zhang T, Yuan HQ, Li DF, Lou HX, Fan PH*. (2017). Mitochondria-targeted lupane triterpenoid derivatives and their selective apoptosis-inducing anticancer mechanisms. Journal of Medicinal Chemistry, 60, 6353-6363.

12. Luo Q, Yan XL, Bobrovskaya L, Ji M, Yuan HQ, Lou HX, Fan PH*. (2017). Anti-neuroinflammatory effects of grossamide from Hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Molecular and Cellular Biochemistry,428(1), 129-137.

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14. Cheng AX, Zhang X, Han XJ, Zhang YY, Gao S, Liu CJ, Lou HX. (2017). Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids. New Phytol. doi:10.1111/nph.14852

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17. Shanren Li, Xiuli Wu, Limei Zhang, Yuemao Shen,* and Liangcheng Du* (2017). Activation of a cryptic gene cluster in Lysobacter enzymogenes reveals a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines. Org. Lett. 19, 5010–5013.

18. Juanli Zhang+, Shanren Li+, Xingkang Wu, Zhixing Guo, Chunhua Lu*, and Yuemao Shen (2017). Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins. Org. Lett, 19, 2442−2445

19. Chunhua Lu, Fei Xie, Chuan Shan, and Yuemao Shen*. (2017). Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum. Appl. Microbiol. Biotechnol. 101, 2273–2279.

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22. Zhiqiang Zhang,Juanli Zhang, Rentai Song, Zhixing Guo, Haoxin Wang, Jing Zhu, Chunhua Lu, and Yuemao Shen* (2017). Ansavaricins A–E: five new streptovaricin derivatives from Streptomyces sp. S012. RSC Adv. 7, 5684–5693.

23. Zhiqiang Zhang, Xingkang Wu, Rentai Song, Juanli Zhang, Haoxin Wang, Jing Zhu, Chunhua Lu, and Yuemao Shen* (2017). Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012. RSC Adv. 7, 14857–14867.

24. Xiaomei Zhang, Mingwei Sun, Hui Shi & Chunhua Lu*.(2017) a-pyrone derivatives from a marine actinomycete Nocardiopsis sp. YIM M13066. Natural Product Research, 2017, 31(19): 2245–224

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29. Hao-Miao Zhu, Bin Sun, Yi-Jun Li, Dan-Hua Meng, Shuang Zheng , Ting-Ting Wang , Feng-Shan Wang , Ju-Zheng Sheng* (2017) KfoA, the UDP-Glucose-4-Epimerase of Escherichia coli strain O5:K4:H4, Shows Preference for Acetylated Substrates, Applied Microbiology and Biotechnology (Accepted). DOI: 10.1007/s00253-017-8639-0

30. Zhipeng Han, Congcong Chen, Caicai Meng, Tian Gao, Peng Peng, Xi Chen, Fengshan Wang*, Hongzhi Cao*. (2017). Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. J. Carbohydr. Chem, in press, DOI: 10.1080/07328303.2017.1315123.

31. Dawa Tsering, Congcong Chen, Jinfeng Ye, Zhipeng Han, Bai-qian Jing*, Xian-wei Liu, Xi Chen, Fengshan Wang, Peixue Ling, Hongzhi Cao*. (2017). Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr. Res, 438, 39-43.

32. Hu, Guixin, Shao, Meng, Gao, Xin, Wang, Fengshan, and Liu, Chunhui*. (2017). Probing cleavage promiscuity of heparinase III towards chemoenzymatically synthetic heparan sulfate oligosaccharides. Carbohydr Polym, 173, 276-285

33. Zhao, Nan, Feng, Zhaolong, Shao, Meng., Cao, Jichao, Wang, Fengshan, and Liu, Chunhui*. (2017). Stability Profiles and Therapeutic Effect of Cu/Zn Superoxide Dismutase Chemically Coupled to O-Quaternary Chitosan Derivatives against Dextran Sodium Sulfate-Induced Colitis. Int J Mol Sci, 18(6), 1121-1135

34. Kang, Dongwei；Fang, Zengjun; Huang, Boshi; Lu, Xueyi; Zhang, Heng; Xu, Haoran; Huo, Zhipeng; Zhou, Zhongxia; Yu, Zhao; Meng, Qing; Wu, Gaochan;Ding, Xiao; Tian, Ye; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe*; Zhan, Peng*; Liu, Xinyong*. (2017). Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. J Med Chem, 60(10), 4424-4443.

35. Dongwei Kang, Xiao Ding, Gaochan Wu, Zhipeng Huo, Zhongxia Zhou, Tong Zhao, Da Feng, Zhao Wang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan*, and Xinyong Liu*. (2017). Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. ACS Medicinal Chemistry Letters, 8 (11), 1188-1193

36. Cheng, Xiqiang； Gao, Ping； Sun, Lin； Tian, Ye； Zhan，Peng*; Liu，Xinyong*. (2017). Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1. Expert Opin Ther Pat, 2, 1-10.

37. Huang, Boshi；Wang, Xueshun；Liu, Xinhao；Chen, Zihui；Li, Wanzhuo；Sun, Songkai；Liu, Huiqing；Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan，Peng*; Liu，Xinyong*. (2017). Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays. Bioorg Med Chem, 25(16), 4397-4406.

38. Jia, Haiyong；Song, Yang；Yu, Ji；Zhan, Peng；Diwakar， Rai； Liang, Xiaohong； Ma, Chunhong； Liu，Xinyong *. (2017). Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors. Eur J Med Chem, 136:144-153.

39. Zhang, Tao; Zhai, Min; Ji, Jianbo; Zhang, Jian; Tian, Ye; Liu, Xinyong*. (2017). Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies. Bioorg Med Chem, 27(11), 2364-2368.

40. Kang, Dongwei; Huo, Zhipeng; Wu, Gaochan; Xu, Jiabao; Zhan, Peng*; Liu, Xinyong*. (2017). Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1. Expert Opin Ther Pat, 27(4), 383-391.

41. Zhang,Heng; Tian, Ye; Kang, Dongwei; Huo, Zhipeng; Zhou, Zhongxia; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. (2017). Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization. Eur J Med Chem, 130, 209-222.

42. Ju, Han; Zhang, Jian; Huang, Boshi; Kang, Dongwe;i Huang, Bing*; Zhan, Peng*; Liu, Xinyong*. (2017). Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives. J Med Chem, 60(9), 3533-3551.

43. Wang,Xueshun; Gao, Ping; Luis, Menéndez-Arias; Liu, Xinyong*; Zhan, Peng*. (2017). Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges. Curr Med Chem, 24, 1-21.

44. Huang, Boshi; Zhou, Zhongxia; Kang, Dongwei; Li, Wanzhuo; Chen, Zihui; Zhan, Peng*; Liu, Xinyong*. (2017). Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2). Expert Opin Ther Pat, 27(1), 9-15.

45. Gao, Ping; Zhang, Lingzi; Sun, Lin; Huang, Tianguang; Tan, Jing; Zhang, Jian; Zhou, Zhongxia; Zhao, Tong; Menéndez-Arias, Luis; Pannecouque, Christophe; De Clercq, Erik; Zhan, Peng*; Liu, Xinyong*. (2017). 1-Hydroxypyr ido[2,3-d]pyrimidin-2(1H)-ones as Novel Selective HIV In­tegrase Inhibitors Obtained via Privileged Substructure-Based Compound Libraries. Bioorg Med Chem, 25(20), 5779-5789.

46. Liu, Zhaoqiang; Tian, Ye; Liu, Jinghan; Huang, Boshi; Kang, Dongwei; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. (2017). Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs. Eur J Med Chem, 140, 383-391.

47. Meng, Qing; Zhao, Tong; Kang, Dongwei; Huang, Boshi; Zhan, Peng*; Liu, Xinyong*. (2017). The development of an effective synthetic route of lesinurad (RDEA594). Chemistry Central Journal, 11(1), 86.

48. Zhan, Peng; Wang, Xueshun; Liu, Xinyong*, Takayoshi, Suzuki. (2017). Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016). Recent Pat Anticancer Drug Discov, 12(1), 16-34.

49. Li, Xiao; Gao, Ping; Huang, Boshi; Zhou, Zhongxia; Yu, Zhao; Yuan, Zheng; Liu, Huiqing; Pannecouque, Christophe; Daelemans, Dirk; De Clercq, Erik; Zhan, Peng*; Liu, Xinyong*. (2017). Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement. European Journal of Medicinal Chemistry, 126:190-201.

50. Chen, Lin; Cheng, Li; Wei，Xinbing; Yuan, Zheng; Wu Yanmei; Wang, Shuaishuai; Ren, Zhiping; Liu, Xinyong; Liu, Huiqing*. (2017). Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson’s Disease Mice. Neurochem Res.42(4), 1141-1150.

51. Wu W, Su J, Tang C, Bai H, Ma Z, Zhang T, Yuan Z, Li Z, Zhou W, Zhang H, Liu Z, Wang Y, Zhou Y, Du L, Gu L and Li, M.Y.^* (2017). cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging. Anal. Chem, 89, 4808-16.

52. Liu J, Tian C, Jiang T, Gao Y, Zhou Y, Li M and Du L.P.^* (2017). Discovery of the First Environment-Sensitive Fluorescent Probe for GPR120 (FFA4) Imaging. ACS Med. Chem. Lett, 8, 428-432.

53. Zhang H, Su J, Lin Y, Bai H, Liu J, Chen H, Du L, Gu L and Li, M.Y.^* (2017). Inhibiting Firefly Bioluminescence by Chalcone. Anal. Chem, 89, 6099-6105.

54. Liu T, Gao Y, Zhang X, Wan Y, Du L, Fang H and Li MY.^* (2017). Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein. Anal. Chem, 89, 11177-11177.

55. Jiang T, Yang X, Zhou Y, Yampolsky I, Du L and Li MY.^* (2017). New bioluminescent coelenterazine derivatives with various C-6 substitutions. Org. Biomol. Chem, 15, 7008-7018.

56. Liu T, Jiang Y, Liu Z, Li J, Fang K, Zhuang C, Du L, Fang H, Sheng C and Li MY.^* (2017). Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction. Medchemcomm, 8, 1668-1672.

57. Jiang T, Zhu P, Du L and Li MY.^* (2018). Identification of AI-2 Quorum Sensing Inhibitors in Vibrio harveyi Through Structure-Based Virtual Screening. Methods Mol. Biol, 1673, 353-362.

58. Gao Y, Lin Y, Liu T, Chen H, Yang X, Tian C, Du L, Li M. (2017). A Bioluminescent Probe for Tumor Hypoxia Detection via CYP450 Reductase in Living Animals. Anal. Chem, doi: 10.1021/acs.analchem.7b03597

59. Ronghua Liu, Qiaofeng Sun, Tian Hu. (2018).Multi-parameters monitoring during traditional Chinese medicine concentration process with near infrared spectroscopy and chemometrics. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 192, 75-81 .

60. Ronghua Liu, Lian Li, Wenping Yin. (2017). Near-infrared spectroscopy monitoring and control of the fluidized bed granulation and coating processes—A review. International Journal of Pharmaceutics. Accepted date: 26 October 2017

61. Jiayue Wang, Tongtong Li, Hailong Yang. (2018). Geographical origin discrimination and polysaccharides quantitative analysis of radix codonopsis with micro near-infrared spectrometer engine . Journal of Innovative Optical Health Sciences, 11（2）:185004(1-11)

62. Qiaofeng Sun, Fei Wang, Lian Li. (2017). Critical process parameters pH value monitoring during human albumin purification with near infrared spectroscopy and chemometrics. Journal of Innovative Optical Health Sciences, 10

63. Tian Hu, Tongtong Li . (2017). Rapid monitoring the water extraction process of Radix Paeoniae Alba using near infrared spectroscopy. Journal of Innovative Optical Health Sciences, 6(10) :1750002.

64. C. Li, F. Wang, L.Zang. (2017). Near infrared spectroscopy combined with multivariate analysis for monitoring the ethanol precipitation process of fraction I + II + III supernatant in human albumin separation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , (175), 17–23.

65. Q. Guo, L. Nie, L. Li. (2017). Estimation of the Critical Quality Attributes for Hydroxypropyl Methylcellulose With Near-Infrared Spectroscopy and Chemometrics. Spectrochim Acta A Mol Biomol Spectrosc, 177, 158-163.

66. Chen, Chen; Hou, Xuben; Wang, Guohua; Pan, Wenyan; Yang, Xinying; Zhang, Yingkai; Fang, Hao∗. (2017). Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors. Eur J Med Chem, 133, 11-23.

67. Su Ran; Hou Zhun; Sang Lihong; Zhou Zhi-ming; Fang Hao; Yang Xinying*. (2017). Enantioseparation of angiotensin II receptor type 1 blockers: evaluation of 6-substituted carbamoyl benzimidazoles on immobilized polysaccharide-based chiral stationary phases. Unusual temperature behavior. J Chromatogr A,1515, 118–128.

68. Xu Guangsen; Liu Tingting; Zhou Yi; Yang Xinying; Fang Hao*. (2017). 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. Bioorg. Med. Chem, 25, 5548-5556.

69. Zhou Yi; Dun Yanyan; Fu Huansheng; Wang Lei; Pan Xiaole; Yang Xinying; Fang Hao*. (2017). Design, synthesis, and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase inhibitor. Chem Biol Drug Des, 90(5), 936-942. DOI: 10.1111/cbdd.13019.

70. Liu Tingting; Wan Yichao; Liu Renshuai; Ma Lin; Li Minyong; Fang Hao∗. (2017). Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors, Bioorg. Med. Chem, 25, 1939–1948

71. Wan Yichao; Liu Tingting; Li Xiaoxian; Chen Chen; Fang Hao∗. (2017). Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains, Bioorg. Med. Chem, 25, 138-152.

72. Mi Yan, Ruixin Ma, Li Jia, Henrietta Venter, Shutao Ma*. (2017). Synthesis and antibacterial activity of novel 3-O-descladinosylazithromycin derivatives. Eur. J. Med. Chem, 127, 874–884.

73. Yinhu Wang, Rumana Mowla, Liwei Guo, Abiodun D Ogunniyi, Taufiq Rahman, Miguel A De Barros Lopes, Shutao Ma*, Henrietta Venter*. (2017). Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance. Bioorg. Med. Chem. Lett, 27, 733–739.

74. Fangchao Bi, Liwei Guo, Yinhu Wang, Henrietta Venter, Susan J. Semple, Fang Liu, Shutao Ma*. (2017). Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition. Bioorg. Med. Chem. Lett, 27, 958–962.

75. Jingru Liu, Shutao Ma*. (2017). Recent development in the discovery of anaplastic lymphoma kinase (ALK) inhibitors for non-small cell lung cancer. Curr. Med. Chem, 24(6), 590-613.

76. Chaobin Jin, Shutao Ma*. (2017). Recent advances in the medicinal chemistry of group II and group III mGlu receptors. MedChemComm, 8, 501–515.

77. Ziteng Zhou, Shutao Ma*. (2017). Recent advances in the discovery of PqsD inhibitors as antimicrobial agents. ChemMedChem, 12, 420–425.

78. Zhiyang Liu, Shutao Ma*. (2017). Recent Advances in Synthetic a-Glucosidase Inhibitors. ChemMedChem, 12, 819–829.

79. Fangchao Bi, Ruixin Ma, Shutao Ma*. (2017). Discovery and Optimization of NAD⁺-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds. Curr. Pharm. Des, 23, 2117–2130.

80. Fang Liu, Henrietta Venter, Fangchao Bi, Susan J. Semple, Jingru Liu, Chaobin Jin, Shutao Ma*. (2017). Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors. Bioorg. Med. Chem. Lett, 27, 3399–3402.

81. Yinhu Wang, Chao Cong, Wern Chern Chai, Ruiqian Dong, Li Jia, Di Song, Ziteng Zhou, Shutao Ma*. (2017). Synthesis and antibacterial activity of novel 4"-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. Bioorg. Med. Chem. Lett, 27, 3872–3877.

82. Li Jia, Mi Yan, Yan Shen, Yinhui Qin, Shengsheng Qiang, Shutao Ma*. (2017). Synthesis and antibacterial evaluation of novel 11-O-carbamoyl clarithromycin ketolides. Bioorg. Med. Chem. Lett, 27, 3693–3697.

83. Ma CC, and Liu ZP*. (2017). Design and synthesis of coumarin derivatives as novel PI3K inhibitors. Anti-Cancer Agents Med. Chem., 17, 395-403.

84. Tan S, He F, Kong T, Wu J*, and Liu Z*. (2017). Design, synthesis and tumor cell growth inhibitory activity of 3-nitro-2H-cheromene derivatives as histone deacetylaes inhibitors. Bioorg. & Med. Chem., 25, 4123–4132.

85. Xie XW, Wan RZ,* and Liu ZP*. (2017). Recent research advances in selective matrix metalloproteinase-13 inhibitors as anti-osteoarthritis agents. ChemMedChem, 12, 1157–1168.

86. Yang Liu, Yanzhen Yin, Zhen Zhang, Carrie J. Li, Hui Zhang, Daoguang Zhang, Changying Jiang, Krystle Nomie, Liang Zhang, Michael L. Wang*, Guisen Zhao*. (2017). Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity. European Journal of Medicinal Chemistry,138: 543-551

87. Dezhi Yang, Dongdong Tong, Qian Zhang, Yongtao Wang, Jing Sun, Fenghe Zhang*, Guisen Zhao*. (2017). Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold. Chem Biol Drug Des, 90, 791–803

88. Li LY, Jiao YN, Jin TY, Sun HX, Li SQ, Jin CR, Hu SY, Ji JB and Xiang L. (2017). Phenolic alkaloid oleracein E attenuates oxidative stress and neurotoxicity in AlCl₃-treated mice. Life Sciences, 191: 211-218.

89. Sun HX, He XQ, Liu CJ, Li LY, Zhou RY, Jin TY, Yue S, Feng D, Gong J, Sun JW, Ji JB, Xiang L. (2017). Effect of oleracein E, a neuroprotective tetrahydroisoquinoline, on rotenone-induced Parkinson’s disease cell and animal models. ACS Chemical Neuroscience, 8 (1), 155-164.

90. Wang PP, Sun HX, Liu DY, Jiao ZZ, Yue S, He XQ, Xia W, Ji JB, Xiang L. (2017). Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose/NaNO₂. Journal of Ethnopharmacology, 203: 252-259.

91. Zhangli Du, Jing Sun, Christie A. Bader, Doug A. Brooks, Minqi Li, Xun Li*, Sally E. Plush*. (2018). Synthesis, photophysical and cellular characterization of folate and methotrexate labelled luminescent lanthanide complexes. J. Inorg. Biochem, 178, 32-42.

92. Xun Li^*. (2018). Gelatinase inhibitors (2011-2017): a patent review. Expert Opinion on Therapeutic Patents, in proof.

93. Leilei Shi, Wei Hu, Jifeng Wu, Hua Zhou, Xun Li^* (2017).. Quinoxalinone as a privileged platform in drug development. Mini-Rev Med Chem, in proof.

94. Zhang, Y.*; Yan, J.; Yao, T-P.* (2017). Discovery of a fluorescent probe with HDAC6 selective inhibition. Eur. J. Med. Chem, In Press, https://doi.org/10.1016/j.ejmech.2017.10.022.

95. Zhou, N.;^# Yan, Y.;^# Liu, C.; Hou, J.; Xu, W.; Zhang, Y.* (2017). Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability. Bioorg. Med. Chem. , 25 (17), 4614-4619.

96. Li, X.;^# Zhang, Y.^#*; Jiang, Y.; Wu, J.; Inks, E. S.; Chou, C. J.; Gao, S.; Hou, J.; Ding, Q.; Li, J.; Wang, X.; Huang, Y.; Xu, W. (2017). Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. Eur. J. Med. Chem, 134, 185-206.

97. Gao, S.; Zang, J.; Gao, Q.; Liang, X.; Ding, Q.; Li, X.; Xu, W.; Chou, C. J.; Zhang, Y.* (2017). Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups. Bioorg. Med. Chem, 25 (12), 2981-2994.

98. Zang, J.; Shi, B. Liang, X.; Gao, Q.; Xu, W.*; Zhang, Y.* (2017). Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity. Bioorg. Med. Chem, 25 (9), 2666-2675.

99. Yan, Y.; Chen, X.; Yang, X.; Xu, W.*; Zhang, Y.* (2017). Sulfoxide Analogs of TAK-875 as GPR40 Agonists: Synthesis, Determination of Absolute Configuration and Biological Activity. Chin. J. Org. Chem, 37 (4), 858-865.

100. Gao, S.; Li, X.; Zang, J.; Xu, W.*; Zhang, Y.* (2017). Preclinical and clinical studies of chidamide (CS055/HBI-8000), an orally available subtype-selective HDAC inhibitor for cancer therapy. Anti-Cancer Agent. ME, 17 (6), 802-812.

101. Zhang PL, Han Y, Zhang LT, Wang XL, Shen T, Ren D, Lou H, Wang XN. Botrysphones A−C and Botrysphins A−F, Triketides and Diterpenoids from the Fungus Botrysphaeria laricina. J. Nat. Prod. 2017, 80, 1791−1797.