1. Zhou J, Zhang J, Li R, Liu J, Fan P, Li Y, Ji M, Dong Y, Yuan H, & Lou H* (2016). Hapmnioides A–C, Rearranged Labdane-Type Diterpenoids from the Chinese Liverwort Haplomitrium mnioides. Organic letters, 18(17), 4274-4276.

2. Zheng H, Dong Y, Li L, Sun B, Liu L, Yuan H, & Lou H* (2016). Novel benzo [a] quinolizidine analogs induce cancer cell death through paraptosis and apoptosis. Journal of medicinal chemistry, 59(10), 5063-5076.

3. Xie F, Chang W, Zhang M, Li Y, Li W, Shi H, Zheng S, & Lou H* (2016). Quinone derivatives isolated from the endolichenic fungus Phialocephala fortinii are Mdr1 modulators that combat azole resistance in Candida albicans. Scientific reports, 6,33687.

4. Li L, Niu H, Sun B, Xiao Y, Li W, Yuan H, & Lou H* (2016). Riccardin DN induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo. Toxicology and applied pharmacology, 310, 175-184.

5. Sun B, Li L, Hu QW, Xie F, Zheng HB, Niu HM, Yuan H, & Lou H* (2016). Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors. European journal of medicinal chemistry, 121, 484-499.

6. Li W, Gao W, Zhang M, Li YL, Li L, Li XB, Chang W, Zhao Z, & Lou H* (2016). p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata. Journal of natural products, 79(9), 2188-2194.

7. Zhou YH, Zhang M, Zhu RX, Zhang JZ, Xie F, Li XB, Chang WQ, Wang XN, Zhao ZT, & Lou HX* (2016). Heptaketides from an endolichenic fungus Biatriospora sp. and their antifungal activity. Journal of natural products, 79(9), 2149-2157.

8. Zheng S, Chang W, Li C, & Lou H* (2016). Als1 and Als3 regulate the intracellular uptake of copper ions when Candida albicans biofilms are exposed to metallic copper surfaces. FEMS yeast research, 16(3), fow029.

9. Gao S, Yu HN, Wu YF, Liu XY, Cheng AX, & Lou HX* (2016). Cloning and functional characterization of a phenolic acid decarboxylase from the liverwort Conocephalum japonicum. Biochemical and biophysical research communications, 481(3), 239-244.

10. Zhang JZ, Qiao YN, Li L, Wang YJ, Li Y, Fei X, Zhou J, Wang X, Fan P, & Lou HX* (2016). ent-Eudesmane-Type Sesquiterpenoids from the Chinese Liverwort Chiloscyphus polyanthus var. rivularis. Planta medica, 82(11/12), 1128-1133.

11. Sun B, Zhang M, Li Y, Hu QW, Zheng HB, Chang WQ, & Lou HX* (2016). Synthesis of riccardin D derivatives as potent antimicrobial agents. Bioorganic & medicinal chemistry letters, 26(15), 3617-3620.

12. Fan P, Li T, Ye Y, Luo Q, Yuan H, & Lou H* (2016). Synthesis and cytotoxic activity of boswellic acid analogues. Phytochemistry Letters, 18, 99-104.

13. Zhou YH, Li XB, Zhang JZ, Li L, Zhang M, Chang WQ, Wang XN Lou HX* (2016). Three new drimane-type sesquiterpenoids, chaetothyrins A–C, from an endolichenic fungus Chaetothyriales sp. Journal of Asian natural products research, 18(5), 409-414.

14. Wang SQ, Zhang QW, Wang XL, Di XX, Wang XN*, & Lou HX*. (2016). Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells. Chinese Chemical Letters, 27(7), 1013-1016.

15. Gao Y*, Sun Q, Liu D, Ma B, Zhao H, Fang Z, Wang H & Lou H.* (2016). A sensitive LC–MS/MS method to quantify methylergonovine in human plasma and its application to a pharmacokinetic study. Journal of Chromatography B, 1011, 62-68.

16. Fan PH^#, Li T^#, Ye YQ, Luo Q, Yuan HQ, Lou HX*. (2016). Synthesis and cytotoxic activity of boswellic acid analogues. Phytochemistry Letters, 18, 99-104.

17. Yan XL, Zhou YF, Tang JJ, Ji M, Lou HX, Fan PH*. (2016). Diketopiperazine Indole Alkaloids from hemp seed. Phytochemistry Letters,18, 77-82.

18. Zhang YY, Xu RX, Gao S, Cheng AX. (2016). Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. FEBS Lett, 590, 2619–2628.

19. Xu RX, Gao S, Zhao Y, Lou HX, Cheng AX. (2016). Functional characterization of a Mg²⁺-dependent O-methyltransferase with coumarin as preferred substrate from the liverwort Plagiochasma appendiculatum. Plant physiol. Biochem, 106, 269-277.

20. Liu M, Li S, Lu CH*.(2016). 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107. Chinese Journal of Natural Medicines, 14(12), 0931-0933.

21. Zhang X, Zhang D, Li WJ*, and Lu CH* (2016). Pseudonocardides A – G, New -Butyrolactones from Marine-derived Pseudonocardia sp. YIM M13669. Helv. Chim. Acta, 99, 191-196.

22. Zhang J, Chang X, Li Y, Lu CH* (2016). Galbonolides from Streptomyces sp. SR107. Natural Product Communications, 11 (12), 1869-1870.

23. JingJing Deng , ChunHua Lu*. (2016) Two new isoflavone 7-O-α-4″-anhydro-4″,5″- didehydroglucuronides from Streptomyces sp. LZ35ΔgdmAI. Natural Products Research. 30 (2)： 180–184,

24. Chunhua Lu,*, Chen Yang and Zhen Xu (2016). Three Naphthoquinones from Streptomyces sp. XZYN-4 Rec. Nat. Prod 10:4: 430-440

25. Mingwei Sun, Zhixing Guo and Chunhua Lu* (2016). Two new polyketides from Nocardiopsis lucentensis DSM 44048. Natural Product Research, 30(9):1036–1041

26. Mingzi Wang, Wei Zhang, Weikai Xu, Yuemao Shen*, and Liangcheng Du* (2016). Optimization of genome shuffling for high-yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants. Appl. Microbiol. Biotechnol. 100, 7491–7498.

27. Xiaomei Li, Jing Zhu, Guoyin Shi, Mingwei Sun, Zhixing Guo, Haoxin Wang, Chunhua Lu*, and Yuemao Shen* (2016). Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins. RSC Adv. 6, 88571–88579.

28. Guoyin Shi, Ning Shi, Yaoyao Li, Wang Chen, Jingjing Deng, Chao Liu, Jing Zhu, Haoxin Wang*, and Yuemao Shen* (2016). D-Alanylation in the assembly of ansatrienin side chain is catalyzed by a modular NRPS. ACS Chem. Biol. 11, 876–881.

29. Shanren Li, Chunhua Lu, Xiaoyan Chang, and Yuemao Shen* (2016). Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. Appl. Microbiol. Biotechnol. 100, 2641–2649.

30. Yanjiao Ding, Yaoyao Li, Zhenyu Li, Juanli Zhang, Chunhua Lu, Haoxin Wang, Yuemao Shen*, and Liangcheng Du* (2016). Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochim. Biophys. Acta 1860, 2097–2106.

31. Zhixing Guo, Xiaoli Li, Jianfang Li, Xuefei Yang, Yuan Zhou, Chunhua Lu*, and Yuemao Shen* (2016). Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium. Biochem. Biophys. Res. Commun. 477, 998–1004.

32. Chuanpeng Liang, Huilin Hao, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, and Yuemao Shen* (2016). Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors. Eur. J. Med. Chem. 121, 272–282.

33. Mengyujie Liu, Chunhua Lu, and Yuemao Shen* (2016). Four new meridamycin congeners from Streptomyces sp. SR107. RSC Adv. 6, 49792–49796.

34. Yanjiao Ding, Zhenyu Li, Yaoyao Li, Chunhua Lu, Haoxin Wang, Yuemao Shen*, and Liangcheng Du* (2016). HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis. RSC Adv. 6, 30895–30904.

35. Chao Lv, Xiaohui Yan, Qian Tu, Yingtong Di, Chunmao Yuan, Xin Fang, Yaacove Ben-David, Lei Xia, Jianxian Gong, Yuemao Shen*, Zhen Yang*, and Xiaojiang Hao* (2016). Isolation and asymmetric total synthesis of perforanoid A. Angew. Chem. Int. Ed. 55, 7539–7543.

36. Danyang Feng, Abdul Sami Shaikh, Fengshan Wang*. (2016). Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines. ACS Chemical Biology (ACS Chem. Biol.), 11, 850-863. DOI: 10.1021/acschembio.6b00084

37. Yan Li, Lian Li, Zhiwei Li, Juzheng Sheng, Xinke Zhang, Danyang Feng, Xu Zhang, Fengxin Yin, Aijun Wang, Fengshan Wang*. (2016). Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops. Biochimica et Biophysica Acta, 1860, 2137-2147.

38. Yuliang Xiao, Pingli Li, Yanna Cheng, Qian Zhang, FengshanWang*. (2016). Effect of a-linolenic acid-modified low molecular weight chondroitin sulfate on atherosclerosis in apoE-deficient mice. Biochimica et Biophysica Acta, 1860, 2589-2597.

39. Lian Li, Yan Li, Danyang Feng, Linghua Xu, Fengxin Yin, Hengchang Zang, Chunhui Liu, Fengshan Wang*. (2016). Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis. Int. J. Mol. Sci., 17, 1685.

40. Li Y, Hou J, Wang F*, Sheng J* (2016) High-throughput assays of leloir-glycosyltransferase reactions: The applications of rYND1 in glycotechnology. Journal of Biotechnology, 227, 10-18. doi: 10.1016/j.jbiotec.2016.04.003

41. Xue J, Jin L, Zhang X, Wang F, Ling P, Sheng J*. (2016). Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor. Biochimica et Biophysica Acta (BBA) - General Subjects, 1860, 844-855. doi: 10.1016/j.bbagen.2016.01.018

42. Yin F-X, Wang F-S*, Sheng J-Z*. (2016). Uncovering the Catalytic Direction of Chondroitin AC Exolyase FROM THE REDUCING END TOWARDS THE NON-REDUCING END. J Biol Chem, 291, 4399-4406. doi: 10.1074/jbc.C115.708396

43. Zhang X, Wang F, Sheng J*. (2016). “Coding” and “Decoding”: hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis. Carbohydrate Research, 428, 1-7. doi: 10.1016/j.carres.2016.04.002

44. Jinfeng Ye, Xian-wei Liu, Peng Peng, Wen Yi, Xi Chen, Fengshan Wang, Hongzhi Cao*. (2016). Diversity-oriented enzymatic modular assembly of ABO histo-blood group antigens. ACS Catal, 6, 8140-8144.

45. Linghua Xu, Xiaohu Ji, Nan Zhao, Chunxia Song, Fengshan Wang, Chunhui Liu*. (2016). The conjugation of Cu/Zn superoxide dismutase (SOD) to O-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (O-HTCC) enhances its therapeutic potential against radiation-induced oxidative damage. Polym. Chem, 7, 1826-1835.

46. Xiaohu Ji, Guixin Hu, Qiongyan Zhang, Fengshan Wang, Chunhui Liu *. (2016). Simultaneous analysis of heparosan oligosaccharides by isocratic liquid chromatography with charged aerosol detection/mass spectrometry. Carbohydr Polym, 152,337-342.

47. Dongwei Kang, Zengjun Fang, Zhenyu Li, Boshi Huang, Heng Zhang, Xueyi Lu, Haoran Xu, Zhongxia Zhou, Xiao Ding, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque *, Peng Zhan*, Xinyong Liu*. (2016). Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles. J Med Chem, 59(17), 7991-8007.

48. Peng Zhan, Christophe Pannecouque, Erik De Clercq *, Xinyong Liu*. (2016). Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends. J Med Chem, 59(7), 2849-78.

49. Chen, Wenmin; Zhan, Peng; Daelemans, Dirk; Yang, Jiapei; Huang, Boshi; De Clercq, Erik; Pannecouque, Christophe*; Liu, Xinyong*. (2016). Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket. Eur J Med Chem, 121, 352-63.

50. Yang, Jiapei; Chen, Wenmin; Kang, Dongwei; Lu, Xueyi; Li, Xiao; Liu, Zhaoqiang; Huang, Boshi; Daelemans, Dirk; Pannecouque, Christophe; De Clercq, Erik; Zhan, Peng*; Liu, Xinyong*. (2016). Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket. Eur J Med Chem, 109, 294-304.

51. Jia, Haiyong; Bai, Fuxiang; Liu, Na; Liang, Xiaohong; Zhan, Peng; Ma, Chunhong; Jiang, Xuemei; Liu, Xinyong *. (2016). Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors. Eur J Med Chem, 123, 202-10.

52. Meng, Qing; Chen, Xuwang; Kang, Dongwei; Huang, Boshi; Li, Wenxin; Zhan, Peng; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe*; Liu, Xinyong*. (2016). Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket. Eur J Med Chem, 115, 53-62.

53. Li, Xiao; Gao, Ping; Huang, Boshi; Zhou, Zhongxia; Yu, Zhao; Yuan, Zheng; Liu, Huiqing; Pannecouque, Christophe; Daelemans, Dirk; De Clercq, Erik; Zhan, Peng*; Liu, Xinyong*. (2016). Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement. Eur J Med Chem, 126, 190-201.

54. Kang, Dongwei; Zhang, Heng; Zhou, Zhongxia; Huang, Boshi; Naesens, Lieve*; Zhan, Peng*; Liu, Xinyong*. (2016). First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach. Bioorg Med Chem Lett, 26(21), 5182-5186.

55. Lu, Xueyi; Li, Xiao; Yang, Jiapei; Huang, Boshi; Kang, Dongwei; Zhao, Fabao; Zhou, Zhongxia; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe*; Zhan, Peng*; Liu, Xinyong*. (2016). Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach. Bioorg Med Chem, 24(18), 4424-4433.

56. Li, Wenxin; Huang, Boshi; Kang, Dongwei; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. (2016). Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors. Chem Biol Drug Des, 88(3), 380-5.

57. Li, Xiao; Huang, Boshi; Zhou, Zhongxia; Gao, Ping; Pannecouque, Christophe; Daelemans, Dirk; De Clercq, Erik; Zhan, Peng*; Liu, Xinyong*. (2016). Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach. Chem Biol Drug Des, 88(2), 241-53.

58. Huang, Boshi; Li, Xiao; Zhan, Peng*; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe; Liu, Xinyong*. (2016). Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents. Chem Biol Drug Des, 87(2), 283-9.

59. Xu, Haoran; Fu, Lu; Zhan, Peng*; Liu, Xinyong*. (2016). 3D-QSAR analysis of a series of S-DABO derivatives as anti-HIV agents by CoMFA and CoMSIA. SAR QSAR Environ Res, 1-16.

60. Huang, Boshi; Liu, Xinhao; Li, Wanzhuo; Chen, Zihui; Kang, Dongwei; Zhan, Peng*; Liu, Xinyong*. (2016). An improved synthesis approach of the HIV-1 inhibitor RDEA427, a pyrrolo[2,3-d]pyrimidine derivative. ARKIVOC, 6, 45 - 51.

61. Zhan, Peng*. (2016). Meet Our Editorial Board Member. Curr Med Chem, 23(16), 1597.

62. Wang, Xueshun; Huang, Boshi; Liu, Xinyong*; Zhan, Peng*. (2016). Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries. Drug Discov Today, 21(1), 118-32.

63. Sun, Lin; Gao, Ping; Zhan, Peng*; Liu, Xinyong*. (2016). Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182. Expert Opin Ther Pat, 26(9), 979-86.

64. Li, Xiao; Gao, Ping; Zhan, Peng*; Liu, Xinyong*. (2016). Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928). Expert Opin Ther Pat. 26(5), 629-35.

65. Huang, Boshi; Kang, Dongwei; Yang, Jiapei; Zhan, Peng*; Liu, Xinyong*. (2016). Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1. Expert Opin Ther Pat, 26(2), 281-9.

66. Huang, Boshi; Zhou, Zhongxia; Kang, Ddongwei; Li, Wanzhuo; Chen, Zihui; Zhan, Peng*; Liu Xinyong*. (2016). Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2). Expert Opin Ther Pat, 25, 1-7.

67. Zhang, Heng; Kang, Dongwei; Huang, Boshi; Liu, Na; Zhao, Fabao; Zhan, Peng*; Liu, Xinyong*. (2016). Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities. Eur J Med Chem, 114, 65-78.

68. Gao, Ping; Sun, Lin; Zhou, Junsu; Li, Xiao; Zhan, Peng*; Liu, Xinyong*. (2016). Discovery of novel anti-HIV agents via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach. Expert Opin Drug Discov, 11(9), 857-71.

69. Chen, Lin; Cheng, Li; Wei, Xinbing; Yuan, Zheng; Wu, Yanmei; Wang, Shuaishuai; Ren, Zhiping; Liu, Xinyong; Liu, Huiqing. (2016). Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3beta Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice. Neurochem Res, 42, 1141-50.

70. Ohya, Susumu*; Kanatsuka, Saki; Hatano, Noriyuki; Kito, Hiroaki; Matsui, Azusa; Fujimoto, Mayu; Matsuba, Sayo; Niwa, Satomi; Zhan, Peng; Suzuki, Takayoshi; Muraki, Katsuhiko. (2016). Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells. Pharmacol Res Perspect, 4(2), e00228.

71. Ke, B.W., Wu, W.X., Gong, D.Y., Hu, X.T., Wei, L. and Li, M.Y.^* (2016). Bioluminescence probe for detecting hydrogen sulfide in vivo. Anal. Chem, 88, 592-5.

72. Zhang, W., Zhou, X.Y., Yu, Q.Y., Du, L.P. and Li, M.Y.^* (2016). Discovery of Naphthalimide Conjugates as Fluorescent Probes for α₁-Adrenoceptors. Chin. Chem. Lett, 27, 185-189.

73. Lin, Y.X., Li, W.H., Yu, Q.Y., Zhou, X.Y., Zhang, W., Du, L.P. and Li, M.Y.^* (2016). Visualization of α₁-Adrenergic Receptors with Phenylpiperazine-based Fluorescent Probes. Sci. China Chem, 59, 624-628.

74. Zhang, H, Bai, H, Jiang, T, Ma, Z, Cheng, Y, Zhou, Y, Du, L and Li, M.Y.^* (2016). Quenching the firefly bioluminescence by various ions. Photochem. Photobiol. Sci, 15, 244-249.

75. Ma, Z., Lin, Y.X., Cheng, Y.N., Wu, W.X., Cai, R., Chen, S.Z., Bai, H.X., Zhang, T.C., Shi, B.K., Han, B., Shi, X.D., Zhou, Y.B., Du, L.P. and Li, M.Y.^* (2016). Discovery of the First Environment-Sensitive Near-Infrared (NIR) Fluorogenic Ligand for α₁-Adrenergic Receptors Imaging in Vivo. J. Med. Chem, 59, 2151-62.

76. Jiang, T.Y., Du, L.P. and Li, M.Y.^* (2016). Light up the bioluminescence with coelenterazine: strategies and applications. Photochem. Photobiol. Sci, 15, 466-480.

77. Yuan, M.L., Jiang, T.Y., Du, L.P. and Li, M.Y.^* (2016). Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation. Chin. Chem. Lett, 27, 550-554

78. Liu, Z.Z., Jiang, T.Y., Wang, B.L., Ke, B.W., Zhou, Y.B., Du, L.P. and Li, M.Y.^* (2016). Environment-sensitive Fluorescent Probe for the Human Ether-a-go-go-Related Gene (hERG) Potassium Channel. Anal. Chem, 88, 1151-5.

79. Tian, C., Du, L., Zhou, Y. and Li, M.Y.^* (2016). Store-operated CRAC channel inhibitors: opportunities and challenges. Future Med. Chem, 8, 817-32.

80. Feng, P., Zhang, H., Deng, Q., Liu, W., Yang, L., Li, G., Chen, G., Du, L., Ke, B. and Li, M.Y.^* (2016). Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model. Anal. Chem, 88, 5610-4.

81. Jiang, T., Yang, X., Yang, X., Yuan, M., Zhang, T., Zhang, H. and Li, M.Y.^* (2016). Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase. Org. Biomol. Chem, 14, 5272-81.

82. Jiang, T.Y.; Wang, W.S.; Wu, X.K.; Wu, W.X.; Bai, H.X.; Ma, Z.; Zhang, L.X. and Li, M.Y.^* (2016). Discovery of New Substrates for LuxAB Bacterial Bioluminescence. Chem. Biol. Drug Des, 88, 197-208.

83. Wu, W.X.; Chen, L.Z. ; Li, J. ; Du, L.P. and Li, M.Y.^* (2016). Bioluminogenic imaging of aminopeptidase N in vitro and in vivo. Method Mol. Biol, 1461, 91-9.

84. Wang B, Liu Z, Ma Z, Li M and Du L.P.^* (2016). Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging. ACS Med. Chem. Lett, 7, 245-9.

85. Jiang, T.; Ke, B.; Chen, H.; Wang, W.; Du, L.P.; Yang, K.Q.; and Li, M.Y.^* (2016). Bioluminescent probe for detecting mercury(II) in living mice. Anal. Chem, 88, 7462-5.

86. Ma, Z,; Liu, Z.; Jiang, T.; Zhang, T.; Zhang, H.; Du, L.P. and Li, M.Y.^* (2016). Discovery of Fluorescence Polarization Probe for the ELISA-Based Antagonist Screening of α1-Adrenergic Receptors. ACS Med. Chem. Lett, 7, 967-71.

87. Yuan, M.; Ma, X.; Jiang, T.; Zhang, C.; Chen, H.; Gao, Y.; Yang, X.; Du, L.P. and Li, M.Y.^* (2016). A novel coelenterate luciferin-based luminescent probe for selective and sensitive detection of thiophenols. Org. Biomol. Chem, 14, 10267-74.

88. Ma, Z.; Lin, Y.; Chen, H.; Du, L.P. and Li, M.Y.^* (2016). A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging. RSC Adv, 6, 102773-7.

89. Ge Lin; Li Kangshuai; Li Mengmeng; Xiao Peng; Hou Xuben; Chen Xu; Liu Hongda; Lin Amy; Yu Xiao; Ren Gui jie; Fang Hao; Sun, Jin-peng∗. (2016). Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase, Bioorg. Med. Chem Lett, 26, 4795-4798.

90. Liu Tingting; Wan Yichao; Liu Renshuai; Ma Lin; Li Minyong; Fang Hao∗. (2016). Improved Antiproliferative Activities of a New Series of 1,3,4-Thiadiazole Derivatives Against Human Leukemia and Breast Cancer Cell Lines, Chem Res Chinese U, 32, 768-774.

91. Liang Tao; Li Jiajie; Fang Jinyu; Liu Tingting; Fang Hao*. (2016). Synthesis and Antiproliferative Activity of Thiadiazole Peptidomimetic Derivatives. Chinese J Org Chem., 2016, 36, 2895-2905.

92. Pan Xiaole; Wang Lei; Dun Yanyan; Fang Hao∗. (2016). Synthesis and Antiproliferative Activity Studies on 2-Substitued Aniline Quinazoline Derivatives, Chinese J Org Chem., 36, 1044-1050.

93. Liu, Renshuai; Wang, Junhua; Tang, Weiping; Fang, Hao∗. (2016). Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors, Bioorg. Med. Chem, 24, 1446-1454.

94. Liu Tingting; Wan Yichao; Fang Hao∗. (2016). Synthesis and Antiproliferative Activity of Novel 1,3,4-Thiadiazole Derivatives, Chinese J Org Chem, 36, 417-424.

95. Li Jia, Shutao Ma*. (2016). Recent advances in the discovery of heparanase inhibitors as anticancer agents. Eur. J. Med. Chem, 121, 209–220.

96. Yinhu Wang, Henrietta Venter, Shutao Ma*. (2016). Efflux Pump inhibitors: A novel approach to combat efflux-mediated drug resistance in bacteria. Curr. Drug Targets, 17, 702–719.

97. Di Song, Shutao Ma*. (2016). Recent development of benzimidazole-containing antibacterial agents. ChemMedChem, 11, 646–659.

98. Shengsheng Qiang, Changde Wang, Henrietta Venter, Xin Li, Yi Wang, Liwei Guo, Ruixin Ma and Shutao Ma*. (2016). Synthesis and biological evaluation of novel FtsZ-targeted 3-arylalkoxy-2,6-difluorobenzamides as potential antimicrobial agents. Chem. Biol. Drug. Des, 87(2), 257–264.

99. Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL*, Liu ZP*. (2016). Design, synthesis, and biological evaluation of 1-methyl-1,4-dihydroindeno[1,2-c]pyrazole analogues as potential anticancer agents targeting tubulin colchicine binding site. J. Med. Chem, 59(11), 5341-5355.

100. Yao YL, Liu ZP*. (2016). Advances in the total synthesis of lactonamycin. Curr. Org. Chem, 20, 1659-1675.

101. Zhang Y, Liu ZP*. (2016). Recent developments of C-aryl glucoside SGLT2 inhibitors. Curr. Med. Chem. 23, 832-884.

102. Jianzhen Liu, Bo Liu, Guangzhu Guo, Yongkui Jing, Guisen Zhao*. (2016). Discovery of novel androgen receptor antagonists: a hybrid approach of pharmacophore-based and docking-based virtual screening. Anticancer Drugs, 26(7), 747-753

103. Jingya Zhang, Linna Zhang, Yuanyou Wang,Guisen Zhao*. (2016). Development of antiangiogenic tyrosine kinases inhibitors: molecular structures and binding modes.Cancer Chemother Pharmacol, 77, 905-926

104. Yang Liu, Yanzhen Yin, Jingya Zhang, Krystle Nomie, Liang Zhang, Dezhi Yang, Michael L. Wang,Guisen Zhao*. (2016). Discovery of 4-(Piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Akt Inhibitors.Arch. Pharm. Chem. Life Sci,349:356-362

105. Guangzhu Guo, Jianzhen Liu, Guanjie Wang, Daoguang Zhang, Jinjie LuGuisen, Guisen Zhao*. (2016). Synthesis and biological evaluation of 3-(4-fluorophenyl)1H-pyrazole derivatives as androgen receptor antagonists.Anticancer Drugs, 27, 278–285

106. Yang Liu, Yijing Li, Jianzhen Liua, Limin Yangc, Pengzhan Li,Guisen Zhao*. (2016). Design, Synthesis and Biological Evaluation of Salicylamide Analogues as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.Letters in Drug Design & Discovery, 13, 314-323

107. Yang Liu, Yijing Li, Jianzhen Liua, Limin Yangc, Pengzhan Li,Guisen Zhao*. (2016). Design, Synthesis and Biological Evaluation of Salicylamide Analogues as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. Letters in Drug Design & Discovery, 13, 314-323

108. Wang PP, Sun HX, Liu CJ, Hu MH, He XQ, Yue S, Jiao ZZ, Xiang L. (2016). Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO₂-induced senescent mice. Phytomedicine, 23, 460-467.

109. Qiao-Hong Xia, Wei Hu, Chen Li, Ji-Feng Wu, Liang Yang, Xue-Mei Han, Yue-Mao Shen, Zhi-Yu Li*, Xun Li^*. (2016). Design, synthesis, biological evaluation and molecular docking study on peptidomimetic analogues of XK469. Eur J Med Chem, 124, 311-325.

110. Liang Yang, Ping Wang, Ji-Feng Wu, Liu-Meng Yang, Rui-Rui Wang, Wei Pang, Yong-Gang Li, Yong-Tang Zheng^*, Xun Li^*. (2016). Design, synthesis and anti-HIV-1 evaluation of hydrazide-based peptidomimetics as selective gelatinase inhibitors. Bioorg Med Chem, 24(9), 2125-2136.

111. Leilei Shi, Jianfeng Zhou, Jifeng Wu, Junya Cao, Yuemao Shen, Hua Zhou, Xun Li*. (2016). Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors. Bioorg Med Chem, 24(8), 1840-1852.

112. Leilei Shi, Jianfeng Zhou, Jifeng Wu, Yuemao Shen, Xun Li^*. (2016). Anti-angiogenic therapy: strategies to develop potent VEGFR-2 tyrosine kinase inhibitors and future prospect. Curr Med Chem, 23(10), 1000-1040.

113. Jiang, Y.; Hou, J.; Li. X.; Huang, Y.; Wang, X.; Wu, J.; Zhang, J.; Xu, W.; Zhang, Y.* (2016). Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity. Bioorg. Med. Chem, 24 (22), 5787-5795.

114. Liang, X.; Zang, J.; Zhu, M.; Gao, Q.; Wang, B.*; Xu, W.; Zhang, Y.* (2016). Design, Synthesis, and Antitumor Evaluation of 4‑Amino-2 (1H)‑pyrazole Derivatives as JAKs Inhibitors. ACS Med. Chem. Lett, 7 (10), 950-955.

115. Li, J.; Li, X.; Wang, X.; Hou, J.; Zang, J.; Gao, S.; Xu, W.; Zhang, Y.* (2016). PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors. Chem. Biol. Drug Des, 88 (4), 574-584.

116. Jiang, Y.; Hou, J.; Li. X.; Xu, W.*; Zhang, Y.* (2016). Design, Synthesis and Biological Evaluation of Novel Tamibarotene Derivative as Multitarget Anticancer Agent. Lett. Drug Des. Discov, 13 (8), 729-733.

117. Jiang, Y.; Li. X.; Hou, J.; Huang, Y.; Jia, Y.; Zou, M.; Zhang, J.; Wang, X.*; Xu, W.*; Zhang, Y.* (2016). Discovery of BC-01, a novel mutual prodrug (hybrid drug) of ubenimex and fluorouracil as anticancer agent. Eur. J. Med. Chem, 121, 649-657.

118. Liang, X.; Huang, Y.; Zang, J.; Gao, Q.; Wang, B.*; Xu, W.; Zhang, Y.* (2016). Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors. Bioorg. Med. Chem, 24 (12), 2660-2672.

119. Jiang, Y.; Li. X.; Li, X.; Hou, J.; Ding, Y.; Zhang, J.; Xu, W.*; Zhang, Y.* (2016). Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU. Med. Chem, 12 (1), 30-36.

120. Ma, C.; Cao, J.; Liang, X.; Huang, Y.; Wu, P.; Li, Y.; Xu, W.; Zhang, Y.* (2016). Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. Eur. J. Med. Chem, 108, 21-27.

121. Zhao LJ^#, Wen Q^#, Yang GT, Huang ZQ, Shen T, Li HZ, Ren DM^*. (2016). Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine. 23(2), 114-122.

122. Shuli Ma, Dawei Zhang, Hongxiang Lou, Longru Sun*, Jianbo Ji. (2016). Evaluation on the immune anti-inflammatory activity of tanshinones in LPS-activited THP-1 Macrophages. Journal of ethnopharmacology, 188, 193-199.

123. Wei Li, Wei Jiang, Shuang Dai and Lei Wang*, Multiplexed detection of cytokines based on dual bar-code strategy and single-molecule counting, Anal. Chem. 2016, 88, 1578-1584.