一、基本情况

沈月毛，男，1965年2月出生，博士，天然药物化学教授，博士生导师，2003年获国家杰出青年科学基金资助。

通讯地址：山东省济南市历下区文化西路44号

TEL: 0531-88382108

FAX: 0531-88382108

Emai: yshen@sdu.edu.cn

二、研究领域

1. 新安莎霉素的定向发掘、生物合成与合成生物学改造

2. 放线菌中新天然产物的发现与活性评价

3. PoTeM家族新成员的定向发掘、生物合成机制与活性机理研究

4. 新型III型分泌系统抑制剂的发现与活性机理研究

三、工作及学习经历

1986.07毕业于安徽师范大学化学系获学士学位，1989.07毕业于中国科学院昆明植物研究所获天然产物化学硕士学位，1995.08-1998.08在美国华盛顿大学化学系留学并从事博士学位论文研究，于1999.11获中国科学院植物学博士学位。1989.07-2004.01在中国科学院昆明植物研究所先后任实习研究员、助理研究员、副研究员和研究员，2004.2-2010.06任厦门大学生命科学学院教授，2010.07至今任山东大学药学院和微生物技术国家重点实验室教授。

四、社会兼职

厦门大学生命科学学院客座教授；中国科学院南海海洋研究所客座教授。

五、教学工作

《天然药物化学》、《有机波谱分析》和《天然产物生物合成》

六、承担课题

主持“天然产物化学生物学”教育部创新团队 (IRT_17R68)，经费：300万元，起止时间：2018.01-2020.12；

主持NSFC重点项目81530091“安莎的新骨架发掘与药用功能导向的结构优化”，经费：273万元，起止时间：2016.01-2020.12。

七、代表性文章

1. Shi YR, Zhang JL, Tian XY, Wu XK, Li TH, Lu CH, Shen YM*. Isolation of 11,12-seco-rifamycin W derivatives reveals a cleavage pattern of the rifamycin ansa chain. Org. Lett. 2019, 21, 900–903.

2. Li XM, Wu XK, and Shen YM*. Identification of the bacterial maytansinoid gene cluster asc provides insights into the Post-PKS modifications of ansacarbamitocin biosynthesis, Org. Lett. 2019 21, 5823–5826.

3. Yaoyao Li, Haoxin Wang, Yan Liu, Yujie Jiao, Shanren Li, Yuemao Shen*, Liangcheng Du* (2018). Biosynthesis of the polycyclic system in the antifungal HSAF and analogues from Lysobacter enzymogenes. Angew. Chem. Int. Ed. 57, 6221–6225.

4. Chuanpeng Liang, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, Yuemao Shen* (2018). Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors. Eur. J. Med. Chem. 143, 85–96.

5. Chuanpeng Liang, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, Yuemao Shen* (2018). Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors. Eur. J. Med. Chem. 143, 85–96.

6. Xiaomei Li, Xingkang Wu, Jing Zhu, Yuemao Shen* (2018). Amexanthomycins A–J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA. Appl. Microbiol. Biotechnol. 102, 689–702.

7. Shanren Li, Xiuli Wu, Limei Zhang, Yuemao Shen,* and Liangcheng Du* (2017). Activation of a cryptic gene cluster in Lysobacter enzymogenes reveals a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines. Org. Lett. 19, 5010–5013.

8. Guoyin Shi, Ning Shi, Yaoyao Li, Wang Chen, Jingjing Deng, Chao Liu, Jing Zhu, Haoxin Wang*, and Yuemao Shen* (2016). D‑Alanylation in the assembly of ansatrienin side chain is catalyzed by a modular NRPS. ACS Chem. Biol. 11, 876−881.

9. Yanjiao Ding, Yaoyao Li, Zhenyu Li, Juanli Zhang, Chunhua Lu, Haoxin Wang, Yuemao Shen*, Liangcheng Du* (2016). Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochim. Biophys. Acta 1860, 2097–2106.

10. Chuanpeng Liang, Huilin Hao, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, and Yuemao Shen* (2016). Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors. Eur. J. Med. Chem. 121, 272–282.

11. Yong Han, Yan Wang, Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen*, Liangcheng Du*. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl. Microbiol. Biotechnol. 2015, 99, 801-8111.

12. Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Guowei Shi, Chunhua Lu, Yuemao Shen*. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors. Chem. Biol. Drug Des. 2015, 85, 181-188.

13. Yaoyao Li, Haotong Chen, Yanjiao Ding, Yunxuan Xie, Haoxin Wang, Ronald L. Cerny, Yuemao Shen*, Liangcheng Du*. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angew. Chem. Int. Edit. 2014, 53, 7524-7530.