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2. Li Y, Sun Y, Zhu MZ, Zhu RX, Zhang JZ, Zhou JC, Wang T, Qiao YN, and Lou HX*. Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H2O2-induced apoptosis of PC12 cells. Phytochemistry, 2019, 162: 173–182.

3. Qiao YN, Sun Y, Shen T, Zhang JZ, Zhou JC, Li Y, Chen W, Ren ZJ, Li YL, Wang X, Lou HX*, Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities. Phytochemistry 2019, 158, 77-85.

4. Li YL, Gao Y, Liu CY, Sun CJ, Zhao ZT, and Lou HX*. Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis. J. Nat. Prod. 2019, 82: 1527-1534.

5. Li YL, Zhu RX, Li G, Wang NN, Liu CY, Zhao ZT, and Lou HX*. Secondary metabolites from the endolichenic fungus Ophiosphaerella korrae. RSC Adv. 2019, 9: 4140=4149.

6. Shi HZ, Chang WQ, Zhang M, Lou HX*. Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation. Chin. J. Nat. Med. 2019, 17: 0209-0217.

7. Li AL^#; Shen T^#; Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XN, Ren DM, Lou HX, Wang XN*. Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis, Free Radical Bio. Med. 2019,141, 21-33

8. Li AL, Li GH, Li YR, Wu XY, Ren DM, Lou HX, Wang XN, Shen T*. Lignan and flavonoid support the prevention of cinnamon against oxidative stress related diseases, Phytomedicine, 2019, 53: 143–153.

9. Zhou MX, Li GH, Wu XY, Sun L, Li YR., Yang WJ, Ren DM, Wang, XN, Xiang L, Lou HX, Shen T*. (2S)-5,6,7,3′,4′-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-induced cytotoxicity via activating Nrf2-mediated defense system. J. Funct. Foods. 2019, 54, 337–347.

10. Yang WJ, He JX, Zhou MX, Huang M, Wang SQ, Wang XN, Lou HX, Ren DM*, and Shen Tao*. An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signaling pathway and prevents oxidative insults in human lung epithelial cells, Free Radical Res. 2019, 53, 3, 348–358.

11. Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, and Shen T*. Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells, Chem-Biol. Interact. 2019, 310, 108741.

12. Wang T, Sun XY, Li AL, Zhou MX, Han Y, Zhang JZ, Ren DM, Lou HX, Wang XN*, and Shen T*. Botrysphin D attenuates arsenic-induced oxidative stress in human lung epithelial cells via activating Nrf2/ARE signaling pathways. Biochem. Biophys. Res. Commun. 2019, 518, 526-532.

13. Xu YL, Xu ZJ, Liu ZP and Lou HX*, Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts. Org. Chem. Front. 2019, 6 (23), 3902-3905.

14. Zhao Y^, Zhang YY , Liu H, Zhang XS, Ni R, Wang PY, Gao S, Lou HX*, Cheng AX^* Functional characterization of a liverworts bHLH transcription factor involved in the regulation of bisbibenzyls and flavonoids biosynthesis. BMC Plant Biol. 2019, 19: 497.

15. Ni R, Zhu TT, Zhang XS, Wang PY, Sun CJ, Qiao YN, Lou HX, Cheng AX^*. Identification and evolutionary analysis of chalcone isomerase-fold proteins in ferns. J. Exp. Bot. doi:10.1093/jxb/erz425

16. Liu H, Xu RX, Zhang XS, Zhu TT, Lou HX, Cheng AX*. The identification and functional characterization of three liverwort class I O-methyltransferases. Phytochemistry, 2019, 159:190-198.

17. Zhang XS, Ni R, Wang PY, Zhu TT, Sun CJ, Lou HX, Cheng AX*. Isolation and functional characterization of two Caffeoyl Coenzyme A 3-O-methyltransferases from the fern species Polypodiodes amoena. Plant Physiol. Biochem. 2019, 136: 169-177.

18. Wang SS, Luo Q, Fan PH*. Cannabisin F from hemp (Cannabis sativa) seed suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia as SIRT1 modulator. Int. J. Mol. Sci. 2019, 20(3): 507.

19. Li T, Wang SS, Fan PH*, Lou HX*. New coumarins and monoterpene galloylglycoside from the stem bark of Sapium baccatum. Fitoterapia, 2019, 134: 435-442.

20. Wang SS^#, Luo Q^#, Zhou YF, and Fan PH*. CLG from hemp seed inhibits LPS-stimulated neuroinflflammation in BV2 microglia by regulating NF-κB and Nrf‑2 pathways. ACS Omega, 2019, 4, 16517−16523.

21. Yang EL, Sun B, Huang ZY, Lin JG, Jiao B*, and Xiang L*. Synthesis, purification, and selective β₂-AR agonist and bronchodilatory effects of catecholic tetrahydroisoquinolines from Portulaca oleracea. J. Nat. Prod. 2019, DOI: 10.1021/acs.jnatprod.9b00418

22. Wang HH, Li G, Qiao YN, Sun Y, Peng XP, and Lou HX*, Chamiside A, a Cytochalasan with a Tricyclic Core Skeleton from the Endophytic Fungus Chaetomium nigricolor F5. Org. Lett. 2019, 21, 3319-3322

23. Ye JF, Xia H, Sun N, Liu CC, Sheng AR, Chi LL, Liu XW, Gu GF, Wang SQ, Zhao J, Wang P, Xiao M, Wang FS, Cao HZ*. Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522. Highlighted in Nat. Catal. News & Views: Kun Huang and Sabine L Flitsch. Glyco-enzymatic cascades get protection. Nat. Catal. 2019, 2, 479-480.

24. Lu N, Ye JF, Cheng JS, Sasmal A, Liu CC, Yao WL, Yan J, Khan N, Yi W, Varki A, Cao HZ*. Redox-controlled site-specific α2,6-sialylation. J. Am. Chem. Soc. 2019, 141, 4547−4552.

25. Sun F, Wang ZD, Yang ZF, Li Y, Cui HF, Liu CH, Gao DZ, Wang FS, and Tan HN*. Characterization, bioactivity and pharmacokinetic study of a novel carbohydrate-peptide polymer: glycol-split heparin-endostatin2 (GSHP-ES2). Carbohyd. Polym., 2019, 207, 79-90.

26. Wang ZD, Li Y, Xing L, Sun F, Yang ZF, Wang FS, and Tan HN*. Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mice. Carbohyd. Polym., 2019, 208, 302-313.

27. Xing L, Sun F, Wang ZD, Li Y, Yang ZF, Wang FS, and Tan HN*. Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate. Int. J Nanomed., 2019, 14, 2573–2589.

28. Yang ZF, Li Y, Sun F, Hou HW, Xing L, Wang ZD, Wang FS, Tan HN*. Improved stability and enhanced anti-tumor activity of hyaluronic acid modified ES2-AF nanoparticle-like conjugate. J Biomed. Nanotechnol. 2019, 15, 1781–1791.

29. Zhang CY, Tang FY, Zhang JJ, Cao JC, Li HJ, Liu CH*. Uncovering the detailed mode of cleavage of heparinase I toward structurally defined heparin oligosaccharides. Int. J. Biol. Macromol. 2019, 141, 756-764.

30. Meng DH, Du RR, Chen LZ, Li MT, Liu F, Hou J, Shi YK, Wang FS, Sheng JZ*, Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes, Microb. Cell. Fact. 18 (2019) 118.

31. Chen LZ, Shi CQ, Yin FX, Wang FS, Sheng JZ*, Cloning and Characterization of a Chondroitin AC Exolyase from Arthrobacter sp. SD-04, Mol. Biotechnol. 61 (2019) 791–800.

32. Shi YR, Zhang JL, Tian XY, Wu XK, Li TH, Lu CH, Shen YM*. Isolation of 11,12-seco-rifamycin W derivatives reveals a cleavage pattern of the rifamycin ansa chain. Org. Lett. 2019, 21, 900–903.

33. Li XM, Wu XK, and Shen YM*. Identification of the bacterial maytansinoid gene cluster asc provides insights into the Post-PKS modifications of ansacarbamitocin biosynthesis, Org. Lett. 2019 21, 5823–5826.

34. Wei FF, Wang ZS, Lu CH, Li YY, Zhu J, Wang HX*, and Yuemao Shen. Targeted discovery of pentaketide ansamycin aminoansamycins A-G, Org. Lett. 2019, 21(19), 7818–7822.

35. Sang ML, Wang HX, Shen YM, Almeida NR, Sheridan MC, Li SR, Li YY*, and Du LC*. Identification of an anti-MRSA cyclic lipodepsipeptide, WBP-29479A1, by genome mining of Lysobacter antibioticus. Org. Lett., 2019, 21, 6432–6436.

36. Chen JN, Wu XK, Lu CH*, Li X*. E17 exerts anti-tumor activity through inhibiting topo II-mediatedchromosomes condensation in CRC cells. Biochem. Biophy. Res. Commun. 2019, 513, 313–318.

37. Xiang WX, Liu Q, Li XM, Lu CH*, Yuemao Shen. Four pairs of proline-containing cyclic dipeptides from Nocardiopsis sp. HT88, an endophytic bacterium of Mallotus nudiflorus L. Nat. Prod. Res. 2019, https://doi.org/10.1080/14786419.2019.1577834

38. Wu Y, Zhang JL, Xiang WX, Wang MZ, Lu CH*. Two new lipodepsipeptides from the endophytic fungus Colletotrichum aotearoa Y41. Rec. Nat. Prod., 2019, 13, 199–204.

39. Li XM, Li XM, Zhu J, Wang HX & Lu CH*, Carbamothioic S-acid derivative and kigamicins, the activated production of silent metabolites in Amycolatopsis alba DSM 44262Δabm9 elicited by N-acetyl-D-glucosamine. Nat. Prod. Res.,2019, DOI: 10.1080/14786419.2019.1574783

40. Li X, Wang HX, Shen YM, Li YY*, and Du LC*. OX4 is an NADPH-dependent dehydrogenase catalyzing an extended Michael addition reaction to form the six-membered ring in the antifungal HSAF. Biochemistry. 2019, DOI: 10.1021/acs.biochem.9b00280.

41. Li X, Wang HX, Li YY*, and Du LC*. Construction of a hybrid gene Cluster to reveal coupled ring formation–hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes. Med. Chem. Comm. 2019, 10, 907–912.

42. Liu T, Dong G, Xu F, Han B, Fang H, Huang Y, Zhou Y, Du L and Li MY^*. Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein. Anal. Chem. 2019, 91:5722-5728

43. Liu ZZ, Li HL, He L, Xiang Y, Tian CS, Li C, Tan P, Jing J, Tian YQ, Du LP, Huang Y, Han L, Li MY^* and Zhou YB. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell. Chem. Biol. 2019, 26, 352-365.

44. Qin X, Ma Z, Yang X, Hu S, Chen X, Liang D, Lin Y, Shi X, Du L and Li MY^*. Discovery of Environment-Sensitive Fluorescent Agonists for α1-Adrenergic Receptors. Anal Chem. 2019, 9, 12173-12180.

45. Lin Y, Ma Z, Li Z, Gao Y, Qin X, Zhang Z, Wang G, Du L and Li MY^*. Bioluminescent Probe for Monitoring Endogenous Fibroblast Activation Protein-Alpha. Anal. Chem. 2019, 91:14873-14878.

46. Liu P, Ma S, Yan C, Qin X, Zhao P, Li Q, Cui Y, Li M and Du LP^*. Discovery of Small-Molecule Sulfonamide Fluorescent Probes for GPR120. Anal. Chem. 2019, 91, 15235-15239.

47. Kang DW, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu GC, Feng D, Wei FJ, Zhang J, Clercq ED, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P* and Liu XY*. Identification of Dihydrofuro[3,4-d] pyrimidine Derivatives as Novel HIV1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. J. Med. Chem. 2019;62(3):1484-501.

48. Huang BS, Chen WM, Zhao T, Li ZY, Jiang XY, Ginex T, Vílchez D, Luque FJ, Kang DW, Gao P, Zhang J, Tian Y, Daelemans D, Clercq ED, Pannecouque C*, Zhan P* and Liu XY*. Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles. J. Med. Chem. 2019;62(4):2083-98.

49. Zhan P*, Kang DW and Liu XY*. Resurrecting the Condemned: Identification of N-Benzoxaborole Benzofuran GSK8175 as a Clinical Candidate with Reduced Metabolic Liability. J. Med. Chem. 2019;62(7):3251-53.

50. Wu GC, Zhao T, Kang DW, Zhang J, Song YN, Namasivayam V, Kongsted J, Pannecouque C, Clercq ED, Poongavanam V, Liu XY* and Zhan P*. Overview of Recent Strategic Advances in Medicinal Chemistry. J. Med. Chem. 2019;62(21):9375-9414.

51. Zhou ZX, Liu T, Wu GC, Kang DW, Fu ZP, Wang Z, Clercq ED, Pannecouque C*, Zhan P* and Liu XY*. Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus. Org. Biomol. Chem. 2019;17(12):3202-17.

52. Wang Z, Yu Z, Kang DW*, Zhang J, Tian Y, Daelemans D, Clercq ED, Pannecouque C, Zhan P* and Liu XY*. Bioorg. Med. Chem. 2019;27(3):447-56.

53. Gao P, Wang XS, Sun L, Cheng XQ, Poongavanam V, Kongsted J, Álvarez M, Luczkowiak J, Pannecouque C, Clercq ED, Lee KH, Chen KH, Liu HQ, Arias LM*, Liu XY* and Zhan P*. Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors. Chem. Biol. Drug. Des. 2019;93(4):582-89.

54. Kang DW, Wang Z, Chen M, Feng D, Wu GC, Zhou ZX, Jing LL, Zuo XF, Jiang XY, Daelemans D, Clercq ED, Pannecouque C, Zhan P* and Liu XY*. Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I. Chem. Biol. Drug. Des. 2019;93(4):430-37.

55. Jing LL, Wu GC, Kang DW, Zhou ZX, Song YN, Liu XY* and Zhan P*. Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors. Drug Discov. Today. 2019;24(2):629-35.

56. Zhang S, Zhang J, Gao P, Sun L, Song YN, Kang DW*, Liu XY* and Zhan P*. Efficient drug discovery by rational lead hybridization based on crystallographic overlay. Drug Discov. Today. 2019;24(3):805-13.

57. Ju H, Zhan P* and Liu XY*. Designing influenza polymerase acidic endonuclease inhibitors via 'privileged scaffold' re-evolution/refining strategy. Future Med. Chem. 2019. doi: 10.4155/fmc-2018-0489.

58. Zhai L, Jia YL, Ji YQ, Zou JM, Liu XY, Gao J and Liu M. Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury. Eur. J. Pharmacol. 2019;844:156-64.

59. Jia RF, Zhang J, Ju H, Kang DW, Fang ZJ, Liu XY* and Zhan P*. Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update). Future Med. Chem. 2019;11(5):375-78.

60. Jiang XY, Hao X, Jing LL, Wu GC, Kang DW, Liu XY* and Zhan P*. Recent applications of click chemistry in drug discovery. Expert Opin. Drug Discov. 2019;1-11.

61. Jiang XY, Yu J, Zhou ZX, Kongsted J, Song YN, Pannecouque C, Clercq ED, Kang DW, Poongavanam V, Liu XY* and Zhan P*. Molecular design opportunities presented by solvent-exposed regions of target proteins. Med. Res. Rev. 2019;39(6):2194-2238.

62. Yu J, Guo XW, Desta S, Zhang S, Zhang J, Ding X, Liang XH*, Jia HY*, Liu XY* and Zhan P*. Design, Synthesis and Evaluation of Novel Heteroaryldihydropyrimidines Derivatives as Non-nucleoside Hepatitis B Virus Inhibitors by Exploring the Solvent-exposed Region. Chem. Biol. Drug Des. 2019. doi: 10.1111/cbdd.13512.

63. Jia RF, Zhang J, Ai W, Ding X, Desta S, Sun L, Sun ZS, Ma XL, Li Z, Wang DF, Huang B*, Zhan P*, Liu XY*. Design, synthesis and biological evaluation of “Multi-Site”-binding influenza virus neuraminidase inhibitors. Eur. J. Med. Chem. 2019; 178:64-80.

64. Zhao T, Meng Q, Kang DW, Ji JB, Clercq ED, Pannecouque C, Liu XY*, Zhan P*. Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing. Eur. J. Med. Chem. 2019; 182:111619.

65. Jing LL, Wu GC, Hao X, Olotu FA, Kang DW, Chen CH, Lee KH, Soliman MES, Liu XY*, Yuning Song*, Zhan P*. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur. J. Med. Chem. 2019 Nov 15; 182:111619. 2019; 183:111696.

66. Gao P, Cheng XQ, Sun L, Song S, Lvarez M, Luczkowiak J, Pannecouque C, Clercq ED, Arias LM*, Zhan P*, Liu XY*. Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase. Bioorg. Med. Chem. 2019;27(17):3836-3845.

67. Wang Z, Yu Z, Kang DW, Zhang J, Tian Y, Daelemans D, Clercq ED, Pannecouque C, Zhan P*, Liu XY*. Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs. Bioorg. Med. Chem. 2019;27(3):447-456.

68. Namasivayam V, Vanangamudi M, Kramer VG, Kurup S, Zhan P, Liu XY, Kongsted J, Byrareddy SN. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic. J. Med. Chem. 2019; 62:4851−4883.

69. Dong Y, Zhao T, Ai W, Zalloum WA, Kang DW, Ting Wu*, Liu XY*, Zhan P*. Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016-2019). Expert Opin. Ther. Pat. 2019;29(11):871-879.

70. Hao X, Zuo XF, Kang DW, Zhang J, Song YN, Liu XY*, Zhan P*. Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors. Expert Opin. Drug Discov. 2019;14(9):915-931.

71. Liang T, Hou X, Zhou Y, Yang X, Fang H*, Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors, ACS Med. Chem. Lett., 10(2019) 1122−1127.

72. Chen C, Nie Y, Xu G, Yang XG, Fang H, Hou X*, Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors, Bioorg. Med. Chem., 27(2019) 2771-2783

73. Liang X, Zang J, Li X, S. T, Huang M, Geng M, Chou CJ, Li C, Cao Y, Xu W, Liu H*, Zhang Y* Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies, J Med. Chem., 11(2019) 1849-1852

74. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun J, Yu X, Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22, J. Biol. Chem. 294(2019) 8653-8663

75. Li Y, Fang H, Hou Z, Sang L, Yang X, An in-line capillary electrophoresis assay for the high-throughput screening of histone deacetylase inhibitors, J. Chromatogr. A, 1591(2019) 171-177

76. Shi XL, Wu JD, Liu P*, Liu ZP*, Synthesis and evaluation of novel GSK-3b inhibitors as multifunctional agents against Alzheimer's disease. Eur. J. Med. Chem. 2019, 167, 211–225.

77. Wang W, Zhao GD, Cui YJ, Li MQ*, Liu ZP*, Synthesis of 1α,25-dihydroxyvitamin D3 analogues with α,α-difluorocycloketone at the CD-ring side chains and their biological properties in ovariectomized rats. J. Steroid Biochem. Mol. Biol. 2019, 186, 66–73.

78. Hong RY, Li X*. Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches. Med. Chem. Comm. 2019, 10, 10-25.

79. Chen JN, Wu XK, Lu CH*, Li X*. E17 exerts anti-tumor activity through inhibiting topo II-mediated chromosomes condensation in CRC cells. Biochem. Bioph. Res. Co. 2019, 513(2), 313-318.

80. Cui YJ, Tang LQ, Zhang CM and Liu ZP*: Synthesis of novel pyrazole derivatives and their tumor cell growth inhibitory activity. Molecules 2019, 24, 279.

81. Wang Y, Liu ZP*: PCSK9 inhibitors: Novel therapeutic strategies for lowering LDL cholesterol. Mini-Rev. Med. Chem. 2019, 19, 165–176.

82. Wu JD, Cui YJ, Zhou YG, Tang LQ, Zhang CM, Liu ZP*: Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties. Invest. New Drugs, https://doi.org/10.1007/ s10637-019-00753-z.

83. Qin YH, Teng YT, Ma RX, Bi FC, Liu ZY, Zhang PP, Ma ST*. Design, synthesis and antibacterial evaluation of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1, 2, 3-triazole side chain. Eur. J. Med. Chem. 2019, 180: 321–339.

84. Bi FC, Song D, Qin YH, Liu XB, Teng YT, Zhang N, Zhang PP, Zhang N, Ma ST*. Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. Bioorg. Med. Chem. 2019, 27: 3179–3193.

85. Zhang N, Ma ST*. Recent development of membrane-active molecules as antibacterial agents. Eur. J. Med. Chem. 2019, 184:111734.

86. Jin CB, Alenazy R, Wang YH, Mowla R, Qin YH, Tan JQE, Modi ND, Gu XJ, Polyak SW, Venter H*, Ma ST*. Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance. Bioorg. Med. Chem. Lett. 2019, 29: 882–889.

87. Zhang PP, Ma ST*. Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. Med. Chem. Comm. 2019, 10: 1329–1341.

88. Ran FS, Liu Y, Zhang DG, Liu MX, Zhao GS*. Discovery of novel pyrazole derivatives as potential anticancer agents in MCL[J]. Bioorg. Med. Chem. Lett. 2019,29(9):1060-1064.

89. Ran FS, Liu Y, Liu MX, Zhang DG, Wang P, Dong JZ, Tang WD, Zhao GS*. Discovery of pyrazolopyrimidine derivatives as potent BTK inhibitors with effective anticancer activity in MCL[J]. Bioorganic Chem. 2019,89.

90. Dong JZ, Zhang JY, Li ZL, Asnake S, Zhang DG, Olsson P*, Zhao GS*. Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists. Med. Chem. Res. 2019, 28(3), 380-386.

91. Yu SP, Liu Y, Zhang Z, Zhang JY, Zhao GS*. Design, synthesis and biological evaluation of novel 2,3-indolinedione derivatives against mantle cell lymphoma. [J]. Bioorg. Med. Chem. 2019,27(15).

92. Sun zy, Fan JJ, Wang JY, Wang F, Nie L, Li L, Dong Q, Li C, Du RR, Quan S, Zang HC. Assessment of the human albumin in acid precipitation process using NIRS and multi-variable selection methods combined with SPA. J. Mol. Struct. 2020,1199:126942.

93. Dong Q, Yu C, Li L, Nie L, Li DY, Zang HC. Near-infrared spectroscopic study of molecular interaction in ethanol-water mixtures[J]. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2019（222）：117183.

94. Dong Q, Yu C, Li L, Nie L, Zhang H, Zang HC. Analysis of hydration water around human serum albumin using near-infrared spectroscopy[J]. Int. J. Biol. Macromol. 2019, （138）：927-932）.

95. Li L, Quan S, Li DY, Wang JY, Zang HC, Zhang LN. Development of near infrared spectroscopy methodology for human albumin determination using a new calibration approach. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2019(217):256-262.

96. Li DY, Li L, Quan S, Dong Q, Liu RC, Sun ZY, Zang HC. A feasibility study on quantitative analysis of low concentration methanol by FT-NIR spectroscopy and aquaphotomics. J. Mol. Struct. 2019 (1182): 197-203.

97. Gao LL, Li TT, Li L, Li Z, Nie L, Zhou HY, Sun ZY, Ye SY, Liu RC, Zang HC. Rapid determination of lumbrokinase potency in the earthworm extract intermediate by near-infrared spectroscopy. Chemometrics Intell. Lab. Syst. 2019 (185): 59–64.

98. Sun ZY, Nie L, Li L, Wang JY, Li W, Cao DW, Wang HY, Du RR, Liu RC, Quan S, Zang HC. Data mean and ratio of absorbance to concentration methods: A novel optimization strategy for near infrared spectroscopy modeling. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2019 (215): 69–80.

99. Li Q, Zhang D, Zhang J, Jiang Y, Song AX, Li ZH, Luan YX*, A three-in-one immunotherapy nanoweapon via cascade-amplifying cancer-immunity cycle against tumor metastasis, relapse, and postsurgical regrowth, Nano Lett.  2019, 19, 9, 6647-6657.

100. Zhang D, Zhang J, Li Q, Song AX, Li ZH, Luan YX*, Cold to hot: rational design of a minimalist multifunctional photo-immunotherapy nanoplatform toward boosting immunotherapy capability, ACS Appl. Mater. Interfaces,  2019, 11, 36, 32633-32646.

101. Zhang J, Zhang D, Li Q, Jiang Y, Song AX, Li ZH, Luan YX*, Task-specific design of immune-augmented nanoplatform to enable high-efficiency tumor immunotherapy, ACS Appl. Mater. Interfaces,  2019, DOI: 10.1021/acsami.9b13556.

102. He WX, Jiang Y, Li Q, Zhang D, Li ZH, Luan YX*, A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: A case of an IR-780 derivative co-assembled with camptothecin prodrug, Acta Biomater. 2019, 84, 356-366.

103. Wu JL, Hu X, Liu RL, Zhang J, Song AX, Luan YX*, pH-responsive and self-targeting assembly from hyaluronic acid-based conjugate toward all-in-one chemo-photodynamic therapy, J. Colloid Interface Sci., 2019, 547, 30-39.

104. Huang CZ, Hu X, Hou ZS, Ji JB, Li ZH, Luan YX*, Tailored graphene oxide-doxorubicin nanovehicles via near-infrared dye-lactobionic acid conjugates for chemo-photothermal therapy, J. Colloid Interface Sci., 2019, 545, 172-183.

105. Ma NX, Song AX, Li ZH, Luan ZH*, Redox-sensitive prodrug molecules meet graphene oxide: an efficient graphene oxide-based nanovehicle toward cancer therapy, ACS Biomater. Sci. Eng., 2019, 5 (3), 1384-1391.

106. Tian HL, Zhang J, Zhang HY, Jiang Y, Song AX, Luan YX*, Low side-effect and heat-shock protein-inhibited chemo-phototherapy nanoplatform via co-assembling strategy of biotin-tailored IR780 and quercetin, Chem. Eng. J., 2019, DOI: 10.1016/j.cej.2019.123043.

107. Jiang Y, Hu X, Zhang J, Jin GX, Luan YX^*, Chlorambucil prodrug-participating catanionic aggregates for sustained drug release and improved antitumor activity, J. Mol. Liq., 2019, 274, 556-561.

108. Mu WW, Jiang DD, Mu SJ, Liang S, Liu YJ* and Zhang N*. Promoting Early Diagnosis and Precise Therapy of Hepatocellular Carcinoma by Glypican-3-Targeted Synergistic Chemo-Photothermal Theranostics. ACS Appl. Mater. Interfaces, 2019, 11, 23591-23604.

109. Wang TQ‡ Zhang J‡ Hou T, Yin XL and Zhang N*. Selective targeting of tumor cells and tumor associated macrophages separately by twin-like core–shell nanoparticles for enhanced tumor-localized chemoimmunotherapy. Nanoscale, 2019, 11, 13934.

110. Pang XP, Wang TQ, Jiang DD, Mu WW, Zhang B, Zhang N*. Functionalized docetaxel-loaded lipid-based nanosuspensions to enhance antitumor efficacy in vivo. Int. J. Nanomed. 2019, 14, 2543-2555.

111. Yao Y, Wang TQ, Liu YJ and Zhang N*, Co-delivery of sorafenib and VEGF-siRNA via pH sensitive liposomes for the synergistic treatment of hepatocellular carcinoma. Artif. Cell. Nanomed. Biotechnol. 2019, 47 (1), 1374-1383.

112. Yin XL, Han LQ, Mu SJ, Mu WW, Liang S, Wang TQ, Liu YJ & Zhang N*, Preparation and evaluation of etoposide-loaded lipid-based nanosuspensions for high-dose treatment of lymphoma. Nanomedicine, 2019, 14(11), 1403–1427.